Augmenting the Body with Medical Engineering

Melissa Knothe Tate
Cleveland, OH

Technology Health & Medical


Melissa Knothe Tate, PhD
Case Western Reserve
Melissa Knothe Tate can discuss, among other things, engineering, mechanical engineering, aerospace and biological engineering.
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Cleveland, OH 44106
Helen Jones-Toms
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Melissa Knothe Tate is an internationally recognized leader in the fields of orthopaedic mechanobiology as well as the development and clinical translation of novel technologies and materials. Dr. Knothe Tate joined the nascent field of orthopaedic mechanobiology two decades ago, as a student at Stanford University, where she earned dual B.S. degrees in Biological Sciences and Mechanical Engineering (1988). Thereafter, she transferred her research and academic pursuits to the Swiss Federal Institute of Technology (ETH) in Zürich, Switzerland, where she earned a Dipl. Masch. Ing., 1994 in Mechanical Engineering and a Ph.D. degree (Dr. sc. techn. ETH, 1998) in Mechanical and Biomedical Engineering. In 1998, she was awarded the Georg Fischer Prize for the most outstanding dissertation at the ETH Zürich.

For several years, Dr. Knothe Tate headed the Bone Mechanobiology Research Group at the AO Research Institute in Davos, as well as the Computational Mechanobiology Research Group at the Institute of Biomedical Engineering in Zürich. She spent the year 2000 as Visiting Professor at the Mt. Sinai School of Medicine Department of Orthopaedics. In January 2001, Dr. Knothe Tate joined the Depts. of Biomedical Engineering and Orthopaedic Surgery at the Cleveland Clinic, where she received several awards for innovation in the R&D sector. In July 2004, joined the faculty of Case Western Reserve University, where she is currently the first Joint Professor of Mechanical & Aerospace and Biomedical Engineering. In addition to being recently elected to the College of Fellows of the American Institute for Medical and Biological Engineering, Dr. Knothe Tate has received prestigious awards from the AO Research Fund, Society for Mathematics and Biology, and the Wallace H. Coulter Foundation. Dr. Knothe Tate’s has placed a priority on cultivation of talent among her trainees, who have earned numerous awards and have gone on to lead their own independent research and development groups. Dr. Knothe Tate has been invited to participate in and to organize conferences for the National Academy of Engineering, the National Science Foundation, the National Institutes of Health, as well as the Humboldt Foundation in Germany. Through the National Science Foundation, Dr. Knothe Tate recently led a new national research initiative in the area of stem cell mechanics during prenatal development, and postnatal growth and healing. Recently, her research has expanded to the areas of cellular and biofluid mechanics as well as development and clinical translation of novel bio-inspired flow directing materials and implants. Dr. Knothe Tate has protected, patented and licensed a number of orthopaedic technologies at the interface of materials, mechanics and biology. She acts as a consultant and expert witness through her private consulting firm, Mechanobiologics International.

Recent Publications/Appearances


December 15, 2011 Data Trends "Implant Device Delivers Stem Cells For Fast Healing Of Serious Bone Injuries"

Decmeber 12, 2011 "It's all in the wrapping -Mimicking periosteum to heal traumatic bone injury"


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